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Completed

NCT Number: NCT03361618

Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway

Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.

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Key information

Conditions

Infertility Unexplained Asthenozoospermia Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Urogenital Diseases

Age range

26 year–36 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Mahmoud Hussein Hadwan

Hillah, Babylon, 51002, Iraq

About this study

The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The presence of asthenozoospermia in the semen sample.
  • Must be unable to reproduce.

Exclusion criteria

  • the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Treatment and study plan

zinc sulfate

Dietary Supplement

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Primary outcomes

  1. Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer.

    Time frame: up to three months.

    Clinical parameter

Secondary outcomes

  1. Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer.

    Time frame: up to three months.

    Enzyme

  2. Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer.

    Time frame: up to three months.

    Enzyme

  3. Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer.

    Time frame: up to three months.

    Enzyme

Sponsors and collaborators

Lead sponsor

Babylon University

Other

Collaborators

  • Ministry of Health, Iraq

Registry information

Official study title

Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway in Spermatozoa and Seminal Plasma of Iraqi Asthenospermic Patients

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Dec 5, 2017
Registry last updated
Dec 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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