Karolinska Institutet, Karolinska University Hospital
Stockholm, 17176, Sweden
Location status: Recruiting
Recruiting
NCT Number: NCT04917471
Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes
To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Type 2 diabetes
Exclusion criteria
Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction <35%) Any condition that interferes with the possibility to fulfill the study protocol
Treatment and study plan
Beet root juice
Dietary Supplement70 ml bid
Placebo Juice
Dietary Supplement70 ml bid
Primary outcomes
-
Percentage recovery of left ventricular function
Time frame: 1 week
Red blood cells are administered to an isolated rodent heart subjected to 25 min global ischemia and 60 min reperfusion. The percentage recovery during reperfusion is determined.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Karolinska Institutet
Other
Registry information
Official study title
The Effect of Dietary Nitrate Supplementation on Red Blood Cell Function in Patients with Type 2 Diabetes
Important dates
- Study start
- 2021
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Jun 8, 2021
- Registry last updated
- Oct 9, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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