Effect of Moderate Alcohol Consumption to Cognitive Functioning After Roux-en Y Gastric Bypass

Objectives: Alcohol metabolism is changed in gastric bypass patients, leading to faster resorption and higher alcohol peak concentrations in blood. Because of stronger alcohol effects after gastric bypass we suggest that also general cognitive function is stronger impaired.

Materials and Methods: We included 28 females (12 gastric bypass patients, 8 obese and 8 normal weight subjects) in the study. Each participant had to drink 250 ml white wine. Directly before, 10-30 min after and 45-65 min after wine consumption cognitive functions were tested by test battery for attentional performance (TAP) from Zimmermann and Fimm. During the whole examination breath-alcohol-contents (BACs) were measured every 5 minutes with breathalyser "Dräger Alcotest 7510".

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Key information

Conditions

Bariatric Surgery Alcohol Consumption Alcohol Drinking Behavior Cognitive Function Drinking Behavior

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Gastric bypass group:

women
preOP BMI >35 kg/m²
time since bariatric surgery > 1 year
age 18-60 years
moderate drinking habits

obese group:

women
BMI >35 kg/m²
age 18-60 years
moderate drinking habits

normal weight group:

women
BMI 18.5 - 25 kg/m²
age 18-60 years
moderate drinking habits

Exclusion criteria

men
patient does not drink wine
usage of psychotropic drugs
alcoholic
pregnancy

Treatment and study plan

250 ml alcohol consumption

Behavioral

Each participant had to drink 250 ml white wine. Directly before, 10-30 min after and 45-65 min after wine consumption cognitive functions were tested by test battery for attentional performance (TAP) from Zimmermann and Fimm. During the whole examination breath-alcohol-contents (BACs) were measured every 5 minutes with breathalyser "Dräger Alcotest 7510".

Primary outcomes

Change in reaction time after alcohol consumption

Time frame: Change measures (baseline, 10 min, 45 min)

Sponsors and collaborators

Lead sponsor

eSwiss Medical & Surgical Center

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2013
First posted: Mar 5, 2015
Registry last updated: Mar 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed