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NCT Number: NCT07616908

Effect of Miralax NPO Time on Residual Gastric Volumes and Bowel Preparation

The goal of this clinical trial is to assess differences in residual gastric volumes after stopping Miralax ingestion at different time points (2, 4, 6 hours) prior to anesthesia induction and compare it to the control (current institutional standard of care where no Miralax is given on the day of surgery).

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Key information

Conditions

Residual Gastric Contents Polyethylene Glycol

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing both EGD and colonoscopy
  • Use of Miralax for cleanout
  • Patients <19 years old

Exclusion criteria

  • Patients with a history of delayed gastric emptying (eg diabetic, GLP-1 intake)
  • Patients with a history of gastric sleeve surgery
  • Use of Golytely for cleanout
  • Emergent EGD/colonoscopies
  • EGD/colonoscopies for foreign body removal and/or decompression
  • Known neurologic compromise
  • Presence of pre-existing ostomy, short bowel syndrome, gastric retention, intestinal obstruction, ileus, bowel perforation, toxic colitis, toxic megacolon, swallowing difficulties
  • Pre-existing electrolyte derangements
  • Allergy to Miralax

Treatment and study plan

Stopping Miralax ingestion 4 hours prior to anesthesia induction

Behavioral

Stopping Miralax ingestion 4 hours prior to anesthesia induction

Stopping Miralax ingestion 6 hours prior to anesthesia induction

Behavioral

Stopping Miralax ingestion 6 hours prior to anesthesia induction

Stopping Miralax ingestion 2 hours prior to anesthesia induction

Behavioral

Stopping Miralax ingestion 2 hours prior to anesthesia induction

Control

Behavioral

Miralax will not be given on the day of surgery

Primary outcomes

  1. Residual gastric volume as measured by EGD

    Time frame: To be performed at the start of the EGD immediately after anesthesia induction.

Secondary outcomes

  1. Preoperative gastric POCUS volume assessment

    Time frame: Performed prior to anesthesia induction

  2. Effectiveness of colonoscopy cleanout

    Time frame: Performed during the colonoscopy portion following upper GI endoscopy (EGD)

    The effectiveness of colonoscopy cleanout will be assessed by the Boston Bowel Preparation Scale (BBPS).

  3. Incidence of aspiration on induction and perioperative aspiration

    Time frame: On anesthesia induction

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jun 1, 2026
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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