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Completed

NCT Number: NCT06677736

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Misr university for science and technology

Giza, Giza Governorate, 3220001, Egypt

About this study

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female
  • Aged below 40 or above 60.
  • Have at least 16 natural teeth excluding wisdom.
  • Provide informed consent and willingness to cooperate with study protocol.
  • Periodontitis stage II patients (23):
  • CAL from 3-4 mm.
  • Radiographic bone loss (15% to 33%).
  • No tooth loss due to periodontitis.
  • Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion criteria

  • 1- Patients with any smoking habits 2- History of antibiotics in the previous three months. 3- Pregnant or lactating female. 4- Treatment with any systemic drug. 5- History of systemic disease. 6- Patients who received periodontal treatment in the last 6 months

Treatment and study plan

conventional scaling and debridement

Procedure

conventional scaling and debridement

diode laser as adjunctive to conventional scaling and debridement

Radiation

Diode laser as adjunctive to conventional scaling and debridement

Primary outcomes

  1. Clinical attachment loss

    Time frame: Base line , follow up after 1 month , second follow up after 6 months

  2. Gingival index

    Time frame: base line, follow up after 1 month, second follow up after 6 months

  3. Toll like receptor - 4

    Time frame: base line, follow up after 1 month, second follow up after 6 months

Sponsors and collaborators

Lead sponsor

Rawda Saleh Saad Alashmawy

Other

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 7, 2024
Registry last updated
Nov 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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