King Edward Medical University Lahore / Mayo Hospital Lahore
Lahore, Punjab Province, 54000, Pakistan
Location status: Recruiting
NCT Number: NCT07488078
The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy).
The main questions it aims to answer are:
Does restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy?
Are there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens?
Researchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes.
Participants will:
Be adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy.
Be randomly assigned to one of two groups:
Group A: Liberal IV fluid administration for 6 hours after surgery.
Group B: Restrictive IV fluid administration for 6 hours after surgery.
Have their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).
Interested in participating?
Request Info18 year–60 year
All sexes
Interventional
Phase 1
Lahore, Punjab Province, 54000, Pakistan
Location status: Recruiting
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
500ml ringer lactate perioperatively given in laparoscopic cholecystectomy patients as compared to traditional 1000ml fluid
1000ml iv fluid given perioperatively in laparoscopic cholecystectomy
Time frame: Day 1
Mean systolic blood pressure at preoperative and 3,6, 12 and 24 hours post operatively
Time frame: Day 1
Mean pulse rate per minute at pre operative, 3,6,12 and 24 hours post operatively
Time frame: Day 1
Mean diastolic blood pressure at pre operative, 3,6,12 and 24 hours post operatively
Time frame: Day 1
Mean pulse pressure at pre operative, 3,6,12 and 24 hours post operatively
King Edward Medical University
Other
Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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