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NCT Number: NCT07488078

Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery

The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy).

The main questions it aims to answer are:

Does restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy?

Are there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens?

Researchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes.

Participants will:

Be adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy.

Be randomly assigned to one of two groups:

Group A: Liberal IV fluid administration for 6 hours after surgery.

Group B: Restrictive IV fluid administration for 6 hours after surgery.

Have their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

King Edward Medical University Lahore / Mayo Hospital Lahore

Lahore, Punjab Province, 54000, Pakistan

Location status: Recruiting

Location contact

Ahmad Uzair Qureshi, FCPS

CONTACT

[email protected]

+923144001410

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients undergoing elective cholecystectomy
  • Age : 18-60 years
  • All genders
  • ASA class 1 and 2

Exclusion criteria

  • History of previous laparotomy
  • Perforated gall bladder
  • Duration of surgery more than 3 hours
  • More than 100ml intra operative blood loss

Treatment and study plan

Lactated Ringer 500ml

Drug

500ml ringer lactate perioperatively given in laparoscopic cholecystectomy patients as compared to traditional 1000ml fluid

Lactated Ringer 1000ml

Drug

1000ml iv fluid given perioperatively in laparoscopic cholecystectomy

Primary outcomes

  1. Mean Systolic Blood Pressure

    Time frame: Day 1

    Mean systolic blood pressure at preoperative and 3,6, 12 and 24 hours post operatively

Secondary outcomes

  1. Mean Pulse Rate Per Minute

    Time frame: Day 1

    Mean pulse rate per minute at pre operative, 3,6,12 and 24 hours post operatively

  2. Mean Diastolic Blood Pressure

    Time frame: Day 1

    Mean diastolic blood pressure at pre operative, 3,6,12 and 24 hours post operatively

  3. Mean Pulse Pressure

    Time frame: Day 1

    Mean pulse pressure at pre operative, 3,6,12 and 24 hours post operatively

Sponsors and collaborators

Lead sponsor

King Edward Medical University

Other

Registry information

Official study title

Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 23, 2026
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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