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NCT Number: NCT07670494

Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery

This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the "peak" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.

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Key information

Conditions

Laparoscopic Cholecystectomy Lung Diseases Lung Injury Mechanical Ventilation Respiratory Tract Diseases Ventilator-Induced Lung Injury

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital

Yenimahalle, Ankara, 06370, Turkey (Türkiye)

Location status: Recruiting

Location contact

arif timuroglu

CONTACT

[email protected]

05072601980

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing elective laparoscopic cholecystectomy surgery.
  • Patients between 18 and 75 years of age.
  • American Society of Anesthesiologists (ASA) physical status I, II or III.
  • Body Mass Index (BMI) between 18.5 and 35 kg/m².
  • Voluntary written informed consent for participation.

Exclusion criteria

  • History of significant chronic obstructive pulmonary disease (COPD) or asthma.
  • Previous lung resection or major thoracic surgery.
  • Heavy smokers (more than 20 cigarettes per day).
  • Presence of spontaneous breathing effort during mechanical ventilation.
  • Conversion from laparoscopic surgery to open surgery during the procedure.
  • Emergency surgery cases.
  • Known pregnancy.

Treatment and study plan

Volume-Controlled Ventilation (VCV)

Device

Participants will be ventilated with the traditional Volume-Controlled Ventilation (VCV) mode. Tidal volume, respiratory rate, PEEP, and I:E ratio will be set according to the study protocol and kept constant during the measurement period.

Pressure-Regulated Volume Control (PRVC)

Device

Participants will be ventilated with the Pressure-Regulated Volume Control (PRVC) mode. This is a hybrid mode that uses a decelerating flow to deliver the target tidal volume at the lowest possible pressure. Settings will be identical to the VCV mode for each patient.

Primary outcomes

  1. Device-Displayed Mechanical Power

    Time frame: At the end of a 10-minute stabilization period in each ventilation mode (VCV and PRVC).

    The mechanical power value (expressed in Joules per minute - J/min) is automatically calculated and displayed on the monitor of the Mindray A9 anesthesia machine. This value represents the total energy delivered by the ventilator to the patient's respiratory system per minute. The study aims to compare how this machine-calculated value differs between the Volume-Controlled Ventilation (VCV) and Pressure-Regulated Volume Control (PRVC) modes under identical clinical conditions.

Study contacts

Contact information is provided by the study sponsor or research team.

arif timuroglu, MD

CONTACT

[email protected]

+905072601980

Sponsors and collaborators

Lead sponsor

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Other

Registry information

Official study title

Comparison of Mechanical Power in Pressure-Regulated Volume Control and Volume-Controlled Ventilation Modes During Laparoscopic Cholecystectomy

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 26, 2026
Registry last updated
Jul 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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