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NCT Number: NCT07337213

Effect of Knee Extensor Training on the Lumbar Spine

The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are:

What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP.

Participants will:

* Exercise three times per week for 8 weeks * Be assessed before, 4 weeks after, and 8 weeks after intervention

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Key information

Conditions

Non Specific Low Back Pain

Age range

40 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

I. Males aged 40 to 60 years, II. nonsmokers, III. with normal body mass index IV. of Saudi nationality, V. office workers, VI. suffering from chronic NLBP for 12 weeks or more with a moderate disability according to the Oswestry Disability Index (score of 21 - 40%) moderate activity level according to the Arabic version of the International Physical Activity Questionnaire short form .

Exclusion criteria

I. Previous spinal surgery, fracture, deformity, or disease. II. Neurological deficit and Lower limb deformity or fracture, or disease. III. Mental or psychological illness. The Arabic version of the Self-Reporting Questionnaire (SRQ-20) developed by the World Health Organization (WHO) to screen for common mental disorders such as depression and anxiety, uses a cut-off score to distinguish between individuals with and without significant psychological distress. A score of 7 or below is generally considered "normal", indicating no significant psychological distress (Al-Subaie et al., 1998).

IV. Systematic chronic illnesses such as hypertension, cardiac and respiratory disorders, and diabetes mellitus.

Treatment and study plan

back strengthening exercise

Other

strengthening exercise to lumbar extensors

OKC Exercise

Other

knee extensor OKC exercise added to the lumbar strengthening exercise

CKC Exercise

Other

knee extensor CKC exercise added to the lumbar strengthening exercise

CKC and OKC Exercise

Other

knee extensor OKC and CKC exercise added to the lumbar strengthening exercise

Primary outcomes

  1. Mean change in the Lumbar lordosis Cobb angle in degrees measured by X-ray

    Time frame: 8 weeks

Secondary outcomes

  1. Mean change of LBP intensity from the baseline measured by Numeric Pain Rating Scale

    Time frame: 8 weeks

    Minimum Value: 0, which represents "no pain". Maximum Value: 10, which represents "worst imaginable pain," "worst possible pain," or "most intense pain imaginable Higher scores indicate a worse outcome

  2. Mean change in the quality of Life score as measured by the Oswestry Disability Index

    Time frame: 8 weeks

    Minimum Value: 0%, which represents the highest possible level of functioning and independence (no disability).

    Maximum Value: 100%, which represents the lowest possible level of functioning and total dependence

  3. Mean change in the muscle strength measured by the Hand-held dynamometer

    Time frame: 8 weeks

    A higher score indicate improvement

  4. Mean change in the posture control measured by the stare exursion test

    Time frame: 8 weeks

    Higher scores mean a better outcome

Study contacts

Contact information is provided by the study sponsor or research team.

Hatem H Allam, Assistant professor

CONTACT

[email protected]

+966543321736

Lamiaa K Elsayyad, Assistant professor

CONTACT

[email protected]

+201095366120

Sponsors and collaborators

Lead sponsor

Lincoln University College

Other

Collaborators

  • Cairo University
  • Taif University

Registry information

Official study title

Knee Extensor-Focused Biomechanical Intervention for Pain, Posture, and Disability in Non-Specific Low Back Pain: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 13, 2026
Registry last updated
Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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