Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07176403

Effect of Intradialytic Exercise on Sleep, Depression and Anxiety in HD Patients

this study aims To assess the effect of intradialytic exercise program on sleep quality, depression and anxiety in HD Patients.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine, Aexandria University

Alexandria, 21526, Egypt

Location status: Recruiting

Location contact

mohamed mamdouh elsayed, MD

CONTACT

[email protected]

00201068055103

About this study

Intradialytic exercise is a common recommendation given to encourage patients to be physically active. Previous studies have suggested that intradialytic exercise is effective in reducing fatigue severity, improving sleep quality, enhancing exercise tolerance, improving quality of life and even psychological status. Research also revealed that intradialytic exercise can increase the efficacy of dialysis, subsequently alleviating inflammation, improving nutrition and bone mineral density. Patients typically undergo two or three hemodialysis sessions a week, with each session lasting for approximately 4 hours. Since many patients maintain bed rest during HD sessions, intradialytic exercise can be a potentially useful approach to improve their health without consuming extra time during the interdialytic period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ESKD patients on maintenance hemodialysis for more than three months.
  • Age more than 18 years.

Exclusion criteria

  • Mentally or physically unfit patients or with severe psychiatric illness.
  • Patients who receive any psychotropic medications.
  • Patients with overt ischemic heart disease or cardiac decompensation.
  • Anemic patients (Hb ≤ 8 mg/dl).
  • Patients presented with severe bone pains or muscle weakness secondary to chronic kidney disease-mineral and bone disorder (CKD-MBD).
  • Patients with advanced lower limbs joints disease.
  • Lower limb amputation.

Treatment and study plan

intradialytic exercise

Other

50 patients will undergo Exercise training program for twelve weeks during hemodialysis session.

  • Type of exercise: aerobic exercise training sessions using a lower limb ergometer.
  • Frequency: three times per week.
  • Duration: thirty minutes per session.

Control Group

Other

50 patients will not perform exercise during hemodialysis session

Primary outcomes

  1. change in sleep quality

    Time frame: 12 weeks

    by using The Pittsburgh sleep Quality Index (PSQI).

  2. change in depression scale

    Time frame: 12 weeks

    by using Beck Depression inventory (BDI)

  3. change in anxiety level

    Time frame: 12 weeks

    by using The Beck Anxiety Inventory (BAI) scoring

Secondary outcomes

  1. effect on dialysis adequacy

    Time frame: 12 weeks

    by assessing urea reduction ratio (URR)

  2. effect on lipid profile

    Time frame: 12 weeks

    by assessing triglycerides and cholesterol

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed mamdouh Elsayed, MD

CONTACT

[email protected]

00201068055103

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Effect of Intradialytic Exercise Program on Sleep Quality, Depression and Anxiety in Hemodialysis Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 16, 2025
Registry last updated
Sep 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.