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Completed

NCT Number: NCT07408895

Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

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Key information

Conditions

Accelerate Tooth Movement

Age range

17 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Sana'a University

Sanaa, Yemen

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy individuals aged 17-29 years (mean age 24 ± 6 years)
  • Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions
  • Full permanent dentition
  • Good oral hygiene
  • Non-smokers
  • Not taking medications affecting bone metabolism (e.g., bisphosphonates)

Exclusion criteria

  • Pregnancy or breastfeeding
  • Contraindications to platelet therapies (e.g., platelet dysfunction)
  • Severe malocclusion unsuitable for fixed appliances
  • Dental anomalies (size/shape)
  • Systemic syndromes

Treatment and study plan

Platelet-Rich Plasma (PRP)

Biological

Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction.

Platelet-rich fibrin (PRF)

Biological

Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction.

Primary outcomes

  1. Rate of Orthodontic Canine Retraction

    Time frame: From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.

    The amount of orthodontic canine movement measured in millimeters.

Sponsors and collaborators

Lead sponsor

Sana'a University

Other

Registry information

Official study title

The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 13, 2026
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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