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NCT Number: NCT06975358

Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection

The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration

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Key information

Conditions

Accelerate Tooth Movement

Age range

16 year–22 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age of the patients ranged from 16: 22 years old.
  • Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
  • Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
  • Good oral hygiene and periodontal condition.

Exclusion criteria

  • Medically compromised patients.
  • Severe crowding in the maxillary arch.
  • Chronic intake of NSAIDs or any medication that interfere with OTM.
  • Previous orthodontic treatment.

Treatment and study plan

Alveolar decortication plus CGF injection

Procedure

Experimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured.

canine retraction without acceleration

Procedure

in the control side, the maxillary canine will be retracted without any acceleration procedure

Primary outcomes

  1. rate of canine retraction

    Time frame: 4 months

Study contacts

Contact information is provided by the study sponsor or research team.

Safa B Alawy, PhD

CONTACT

[email protected]

0201009088252

Sponsors and collaborators

Lead sponsor

Safa Basiouny Alawy

Other

Registry information

Official study title

Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 16, 2025
Registry last updated
Jun 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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