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Completed

NCT Number: NCT05798416

Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude

High altitude (>2400 m) is associated with decreased atmosphere pressure leading to hypoxia which in turn impairs exercise capacity and causes acute mountain sickness (AMS). It is noted that adding CO2 might be beneficial to improve hypoxia and exercise performance at high altitude. However, no device is currently available that can supply a constant low dose of CO2 during free movement at high altitude. We have recently invented a portable device which is small and light enough for supplement of low dose CO2 during field exercise at high altitude.

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Key information

Conditions

High Altitude Acute Mountain Sickness Altitude Sickness Carbohydrate Metabolism, Inborn Errors Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases Genetic Diseases, Inborn Inhalation; Gas Lysosomal Storage Diseases Metabolic Diseases Metabolism, Inborn Errors Mucinoses Mucopolysaccharidoses Mucopolysaccharidosis IV Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Skin and Connective Tissue Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

About this study

Objective: To determine whether the supplement of low-dose CO2 by the novel device could improve exercise performance at high altitude.

Methods: The lowlanders (<500m) who have no history of travelling to high altitude (>1000m) a year before the study will be recruited. And the subjects who are high-altitude residents and have not left high altitude over the last twelve months will also be recruited for the study. Subjects will be randomly and blindly given either CO2 mixed with air or air alone during endurance shuttle walking test (ESWT). Blood gases will be measured before and after inhalation of CO2. ESWT time, ventilation per minute (VE), blood oxygen saturation (SPO2), and end-tidal CO2 concentration (ETCO2) will be measured during exercise and will be compared during inhalation of CO2 and during inhalation of ambient air.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy lowlanders (<500m) who have no history to travel to high altitude (>1000m) a year before the study.
  • Healthy high altitude (4500m) residents who have not left the inhabited area over the last twelve months before the study.

Exclusion criteria

  • Subjects with cardiovascular diseases, respiratory diseases and neuromuscular diseases which could affect exercise.

Treatment and study plan

Exercise under inhalation CO2

Drug

Participants perform shuttle walk test at high altitude while using the novel portable device for inhalation of CO2

Other names: inhalation of low dose CO2

Exercise under inhalation ambient air

Other

Participants perform shuttle walk test at high altitude while inhaling ambient air

Primary outcomes

  1. Change of the distance in walking test

    Time frame: 48 hours

    Changes in walking distance under inhalation of CO2 and ambient air

Sponsors and collaborators

Lead sponsor

State Key Laboratory of Respiratory Disease

Other

Registry information

Official study title

Effect of Supplement of CO2 Using Novel Portable Device on Exercise Performance at High Altitude

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Apr 4, 2023
Registry last updated
May 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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