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Completed

NCT Number: NCT06060145

Effect of Indoor Plants on Cardiopulmonary System

This is a randomized controlled human exposure crossover study, aims to explore the health benefits of indoor plants on cardiopulmonary system on adults.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhejiang Chinese Medicine University

Huangzhou, Zhejiang, 310000, China

About this study

The researchers will conduct a randomized cross-controlled trial involving 48 healthy adults in Hangzhou, China. These participants will be randomly assigned into two groups, each comprising 24 individuals. Each participant will undergo two separate exposures in an office setting: one exposure without any plants present, and another exposure with 34 to 38 potted plants. A washout period of at least 4 weeks will be implemented between the two exposures. Questionnaires, physical examinations and the collection of biological samples will be conducted prior to exposure and after exposure. In addition, the monitoring of negative air ion, air pollutants and noise exposure, as well as collection of environmental microbial samples, will be conducted on weekdays. Researchers will gather samples of blood, urine, nasal secretion, and exhaled breath condensate from participants.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Living in Hangzhou during the study period;
  • Non-smoking, no history of alcohol or drug abuse;
  • Staying indoors in daytime we required.

Exclusion criteria

  • Current or ever smokers;
  • Subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy;
  • Subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension;
  • Subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
  • Subjects with chronic disease, such as diabetes, chronic hepatitis, and kidney disease;
  • Subjects with a history of major surgery;
  • Medication use or dietary supplements intake in recent two months;
  • Unable to cooperate with follow-up.

Treatment and study plan

Plants placed in an office environment

Other

The intervention group will be provided with an intervention consisting of 34-38 potted plants arranged in an office environment for a duration of 8 hours (09:00-17:00) on weekdays (Monday to Friday) for 4 weeks.

Devoid of any plant presence in an office environment

Other

Participants assigned to the control group will be exposed to an office environment devoid of any plant presence for a duration of 8 hours (09:00-17:00) on weekdays (Monday to Friday) for 4 weeks.

Primary outcomes

  1. Forced Vital Capacity(FVC)

    Time frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure forced vital capacity (FVC) of lung function.

Secondary outcomes

  1. Blood Pressure(BP)

    Time frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure systolic blood pressure (SBP) and diastolic blood pressure (DBP).

  2. Heart Rate Variability(HRV)

    Time frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure Heart Rate Variability (HRV).

Other outcomes

  1. C-reactive protein(CRP)

    Time frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure serum concentrations of C-reactive protein(CRP)

  2. Interleukin-6(IL-6)

    Time frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure the serum concentrations of Interleukin-6

  3. Tumor necrosis factor-α(TNF-α)

    Time frame: Time Frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.

    We plan to measure the serum concentrations of Tumor necrosis factor-α

Sponsors and collaborators

Lead sponsor

Lina Zhang

Other Gov

Collaborators

  • Zhejiang Chinese Medical University

Registry information

Official study title

Effect of Indoor Plants on Cardiopulmonary System: a Randomized, Crossover, Controlled Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 29, 2023
Registry last updated
Jul 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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