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OpenTrials
Completed

NCT Number: NCT01913171

Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression

o determine effects of hula-hooping on android obesity, metabolic parameters and adipose tissue (AT) gene expression.

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Key information

Conditions

Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Abdominal Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Medicine, University of Helsinki

Helsinki, FI-00290, Finland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 18 and 70 years
  • central adiposity as measured by the waist circumference (>80 cm in females and >94 cm in males) (9)
  • ability to hula-hoop for a minimum of 2 minutes and to have the necessary space available for this activity either at home or at work
  • ability to communicate meaningfully with the investigator and legal competence to provide written informed consent

Exclusion criteria

  • clinical or biochemical evidence of disease other than obesity as judged by history, physical examination and standard laboratory tests
  • excessive use of alcohol, i.e., over 20 g/day
  • use of medications known to affect glucose or lipid metabolism and
  • pregnancy or lactation

Treatment and study plan

Exercise

Other

Primary outcomes

  1. Android obesity

    Time frame: 6weeks

    The primary objective was to evaluate the change in the % fat in the android region as measured by DEXA during 6 weeks of HULA as compared to WALK

Secondary outcomes

  1. metabolic parameters

    Time frame: 6weeks

    The secondary objectives included the comparison of differences in waist circumference (cm), relative and absolute trunk and limb muscle mass as measured by DEXA (% and kg), fasting plasma glucose (mmol/l), fasting serum insulin (mU/l), liver enzymes (U/l), fasting plasma LDL and HDL cholesterol and triglycerides (mmol/l). Gene expression was analyzed in adipose tissue biopsies collected before and after each exercise intervention.

Other outcomes

  1. adipose tissue inflammation

    Time frame: 6weeks

    To determine the effects of HULA compared to WALK on adipose tissue inflammation, a needle aspiration biopsy of abdominal s.c. adipose tissue was taken under local anesthesia with lidocaine before and after each exercise intervention. The adipose tissue sample was immediately frozen in liquid nitrogen and then stored at -80°C until analysis. Total RNA from s.c. AT was isolated.Relative quantification for the genes of interest (see list below) was carried out using normalization to the 36B4 and β-actin mRNA values.

    ABCA1 Adiponectin ANGPTL8 CHOP CD4 CD8 CD68 ETFDH FOXP3 GLUT4 MCP-1 MRC-1 PGC-1α VEGF-A β-actin

Sponsors and collaborators

Lead sponsor

University of Helsinki

Other

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jul 31, 2013
Registry last updated
Jul 31, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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