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OpenTrials
Completed

NCT Number: NCT01256957

Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health

The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.

Completed

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Key information

Conditions

Endothelial Function Oxidative Stress Systemic Inflammation

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Simon Fraser University

Burnaby, British Columbia, V5A 1S6, Canada

About this study

The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 19 years or older
  • Non-smoking household
  • Lives in study region (Smithers or Telkwa British Columbia)

Exclusion criteria

-

Treatment and study plan

HEPA Filter

Device

Other names: Honeywell model 50300, Honeywell model 18150

Primary outcomes

  1. Reactive hyperemia index

    Time frame: After 1 week of air filtration

Secondary outcomes

  1. C-reactive protein

    Time frame: After 1 week of filtration

Sponsors and collaborators

Lead sponsor

Simon Fraser University

Other

Collaborators

  • Health Canada
  • Ministry of Environment, British Columbia
  • University of British Columbia

Registry information

Official study title

Assessing the Impact of Wood Stove Interventions on Air Quality

Acronym: WEST

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Dec 9, 2010
Registry last updated
Dec 5, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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