Skip to main content
OpenTrials
Completed

NCT Number: NCT07712302

Effect of GMI With and Without NM on LE in Cancer Patients With CIPN

The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are:

- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chemotherapy Induced Peripheral Neuropathy (CIPN) Ataxia Cancer Dyskinesias Neoplasms Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms

Age range

31 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Faisalabad

Faisalābad, Punjab Province, 38000, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both male and female
  • Age ranging from 31 to 65 years
  • Diagnosed cancer patients (stage 1 to 3, cancer of any kind)
  • Chemotherapy sessions (antineoplastic drugs) - at least 1 session
  • Presence of glove and stocking peripheral neuropathy
  • LANSS score greater than 12
  • Agreed to give complete follow-up

Exclusion criteria

  • Any co-morbid conditions that can cause peripheral neuropathy e.g. diabetes, chronic kidney failure
  • Any trauma history that can cause peripheral neuropathic symptoms
  • Pre-existing nerve entrapment syndromes
  • Diagnosed stage 4 cancer patients
  • Cancer patients taking palliative chemotherapy

Treatment and study plan

Graded motor imagery

Other

Graded motor imagery is a series of three steps. The first step, lateral recognition, includes graded left and right judgment exercises. The second step involves imagining the performance of movements and the third, and last step involves performing movements in front of a mirror.

Neural Mobilization

Other

Nerve mobilization allows movement between structures of nervous system and its surrounding areas. It is used to mobilize the nervous system and maintain equilibrium inside the nervous system as well as in structures present in its surroundings.

Primary outcomes

  1. LANSS

    Time frame: Baseline, week 3 (mid-intervention), week 6 (post intervention)

    Leeds Assessment of Neuropathic Symptoms and Sign

Secondary outcomes

  1. Romberg Test

    Time frame: Baseline, week 6 (post-intervention)

    Quantitative version of Romberg Test

  2. EORTC-QLQ-CIPN20

    Time frame: Baseline, week 6 (post-intervention)

    European Organization of Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy Induced Peripheral Neuropathy 20

Sponsors and collaborators

Lead sponsor

University of Faisalabad

Other

Registry information

Official study title

Effect of Graded Motor Imagery With and Without Neural Mobilization on Lower Extremity in Cancer Patients With Chemotherapy-induced Peripheral Neuropathy

Acronym: CIPN

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.