Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study

To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hvidovre University Hospital

Hvidovre, Danmark, 2650, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participation in previous study (NCT01559779)

Exclusion criteria

Pregnancy/lactation
Major chronic disease develop since previous examination with possible impact on outcomes

Treatment and study plan

Primary outcomes

Change in islet cell function from baseline (preoperatively)

Time frame: >24 months

Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass

Secondary outcomes

Change in glucose tolerance during oral glucose tolerance test

Time frame: >24 months

Fasting, peak and nadir glucose during oral glucose tolerance test
Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass

Time frame: >24 months

Differences in arterial and venous plasma glucose during oral glucose stimulation

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2014
First posted: Jun 12, 2014
Registry last updated: Apr 7, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed