Effect of Fasting on the Size of Abdominal Lymphatic Tumors in Women

Lymphangioleiomyomatosis (LAM) is a rare disease of women that is characterized by a proliferation of abnormal smooth muscle-like cells (LAM cells) in the lungs, which leads to cystic destruction of the lung parenchyma, in the axial lymphatics, resulting in lymphangioleiomyomas, and in abdominal angiomyolipomas, primarily in the kidneys. Lymphangioleiomyomas may cause abdominal distension and compress abdominal organs, producing obstipation, bladder obstruction and neurological deficits. Leakage of chyle may be responsible for ascites and pleural effusions. The lymphangioleiomyomas may change in size during the day. This variation in tumor size may be due to increased chyle formation or alterations in lymphatic flow. These studies however, were not performed with research subjects who were fasting. Our hypothesis is that the ingestion of food increases chyle formation and lymphatic flow, which in turn increases the size of the lymphangioleiomyomas. The aim of this study is to test this hypothesis. We propose to conduct a study in 30 LAM patients who have lymphangioleiomyomas to determine whether the ingestion of food, by increasing chyle formation and lymphatic flow, increases the size of the lymphangioleiomyomas.

• INCLUSION CRITERIA:

Individuals who are 18 years of age or older with any of the following:

• Lymphangioleiomyomatosis
• Abdominal or pelvic lymphangioleiomyomas equal to or greater than one centimeter in diameter in the non-fasting state.

Exclusion criteria

Individuals with any of the following:

• Lung transplantation
• Kidney transplantation
• Lymphangioleiomyomas smaller than one centimeter in diameter in the non-fasting state.
• Pregnancy or lactation.
• Type 1 diabetes.
• Inability to give informed consent.
• Currently taking rapamycin.