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Completed

NCT Number: NCT01922973

Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults

The overall objective of this study is to determine the extent to which circulating ghrelin levels (total and bioactive ghrelin) are regulated by nutritional state and age.

Completed

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Key information

Conditions

Aging

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

About this study

Normal volunteers: young and older men and women studied under fed and fasting (total 62.5h) conditions, frequent blood sampling for ghrelin and other related hormones

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy young (ages 18-30) and older (ages > 60) men and women with a body mass index (BMI) of <35 kg/m2. Young and older subjects will be matched for BMI.

Exclusion criteria

  • A history of coronary artery disease, congestive heart failure, peripheral vascular disease, diabetes mellitus, significant hypertension (BP >180 systolic or >100 diastolic at rest); renal, hepatic, pulmonary disease; untreated hypothyroidism, untreated hyperthyroidism; history of seizure disorder; history of malignancy (other than some skin cancers), history of active chronic infections (e.g., HIV, tuberculosis): abnormal screening laboratory tests. This information will be obtained through the use of screening labs, history and physical exam and the medical record. See the GCRC protocol for details of the labs.
  • Hematocrit < 41% men, < 38% women
  • History of daily tobacco use within past 3 months
  • Chronic alcohol abuse
  • Recent weight change of > 10 pounds in last 3 months
  • Strenuous exercise for average of more than 60 min/day
  • Investigational drug within past 6 weeks
  • Any history of major psychosis, severe depression, anorexia nervosa
  • Transmeridian travel within 2 weeks prior to or during study -

Treatment and study plan

Fasting

Other

normal volunteers fast from food on one occasion for 62.5 h; on another occasion fed 3 meals

Primary outcomes

  1. Ghrelin concentration

    Time frame: 24-h mean

Sponsors and collaborators

Lead sponsor

University of Virginia

Other

Registry information

Important dates

Study start
2003
Primary completion
2004
Study completion
2004
First posted
Aug 14, 2013
Registry last updated
Aug 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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