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NCT Number: NCT07268859

Effect of Fan Application in Preventing Ticagrelor-Associated Dyspnea

This study will be conducted in the coronary intensive care unit of Dr. Siyami Ersek Chest, Heart and Vascular Surgery Training and Research Hospital. It aims to investigate the effect of hand fan therapy on ticagrelor-associated dyspnea in patients receiving ticagrelor.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

İstanbul Üniversitesi-Cerrahapaşa, Istanbul, Avcılar, Turkey (Türkiye)

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About this study

Patients in the coronary intensive care unit receiving ticagrelor and meeting the inclusion criteria will be included. The study includes two groups: a control group receiving standard care and an experimental group receiving standard care plus hand fan therapy. A total of 110 participants (55 per group) will be recruited. Randomization will be performed using a computer-based randomization program. Due to the nature of the intervention and sample characteristics, participants and the researcher will not be blinded. Data will be analyzed by a statistician not involved in the study, and the findings will be reported.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18 and 65,
  • No severe hearing and vision problems,
  • Can speak and understand Turkish,
  • Easy to communicate with,
  • First-time sufferer of acute coronary syndrome (ACS) for the first time,
  • Decided to start ticagrelor therapy,
  • Able to adapt to treatment,
  • Individuals who volunteered to participate in the research.

Exclusion criteria

  • Having any problem that prevents you from communicating cognitively, emotionally and verbally,
  • Obstructive sleep abnormalities,
  • Have a disease that affects respiratory function (stage IV cancer, bronchial asthma, COVID-19, lung cancer, pulmonary edema, chronic obstructive pulmonary disease, pulmonary hypertension, pulmonary embolism, pneumonia or bronchitis, etc.),
  • With metabolic abnormalities,
  • Intubated after the procedure,
  • Previously treated with ticagrelor,
  • Individuals who did not volunteer to participate in the study. Losses to follow up
  • Individuals who wish to leave the study voluntarily.
  • Saturation value below 95%,
  • The one with the arrest,
  • Who will not be able to fulfill the requirements of the work,
  • Individuals with life-threatening conditions

Treatment and study plan

standart care

Other

Routine ward care including semi-Fowler position and breathing exercises. Standard institutional care will be applied. Presence, number, and severity of dyspnea attacks will be recorded during the first 2 hours after ticagrelor administration.

STANDART CARE & FAN THERAPY

Other

In addition to standard care, patients will undergo hand fanning for 5 minutes at 30, 60, and 120 minutes after ticagrelor administration. The fan will be directed toward the patient's face from a distance of ~15 cm. Dyspnea severity and number of episodes will be recorded during this period.

Other names: Fan

Primary outcomes

  1. Incidence of ticagrelor-associated dyspnea

    Time frame: Time Frame: 0-120 minutes after ticagrelor administration (T1: baseline; T2: 30 min; T3: 60 min; T4: 120 min) Unit of Measure: Percentage of participants (%)

    The proportion of participants who experience dyspnea within 120 minutes following ticagrelor administration will be recorded.

Secondary outcomes

  1. Time to onset of ticagrelor-associated dyspnea

    Time frame: Time Frame: Within 120 minutes after ticagrelor administration (T1-T4) Unit of Measure: Minutes (min)

    The time interval between ticagrelor administration and the first reported dyspnea episode will be measured in minutes.

Other outcomes

  1. Severity of ticagrelor-associated dyspnea

    Time frame: Time Frame: 0-120 minutes after ticagrelor administration (T1: baseline; T2: 30 min; T3: 60 min; T4: 120 min) Unit of Measure: Score (0-10)

    Dyspnea severity will be assessed using the Modified Borg Dyspnea Scale (0-10) at T1 (baseline), T2 (30 min), T3 (60 min), and T4 (120 min) after ticagrelor administration. Higher scores indicate greater symptom severity.

Study contacts

Contact information is provided by the study sponsor or research team.

Arzu ERKOÇ, Associate professor

CONTACT

[email protected]

+905552735500

Emine Tuğba YORULMAZ, research assistant

CONTACT

[email protected]

+905556177281

Sponsors and collaborators

Lead sponsor

Acibadem University

Other

Registry information

Official study title

Effect of Fan Application in Preventing Ticagrelor-associated Dyspnea in Patients With Acute Coronary Syndrome.

Acronym: ACS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 8, 2025
Registry last updated
Dec 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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