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OpenTrials
Completed

NCT Number: NCT01008345

Effect of Ezetimibe on Oxidized Low-density Lipoprotein (LDL) Cholesterol

Randomized study. Patients with coronary artery disease equivalent will be randomized to receive atorvastatin 40 mg/day + placebo vs. atorvastatin 40 mg/day + ezetimibe 40 mg/day. Oxidized LDL cholesterol will be measured at baseline and after 8 weeks of treatment. Hypothesis is that ezetimibe will lower oxidized LDL

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Heart Diseases Metabolic Diseases Myocardial Ischemia Nutritional and Metabolic Diseases Vascular Diseases

Age range

21 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hotel Dieu de France Hospital

El Achrafiyé, Beirut, 0000, Lebanon

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CAD or CAD equivalent

Exclusion criteria

  • Prior CABG or PCI within 3 months Prior use of ezetimibe within 3 months Receiving atorvastatin 40 mg/day or 80 mg/day or any dose of rosuvastatin CHF NYHA stage >2 Creatinin clearance < 30 ml/min

Treatment and study plan

ezetimibe

Drug

Patients will receive 10 mg/day of ezetimibe for 8 weeks

Primary outcomes

  1. level of oxidized LDL cholesterol at end of study

    Time frame: 8 weeks of treatment

Secondary outcomes

  1. small dense LDL level

    Time frame: 8 weeks of treatment

Sponsors and collaborators

Lead sponsor

Hotel Dieu de France Hospital

Other

Collaborators

  • Pharmaline, Lebanon

Registry information

Official study title

Effect of Ezetimibe on Oxidized LDL Cholesterol

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Nov 5, 2009
Registry last updated
Nov 6, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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