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NCT Number: NCT01775163

Effect of Exercise-Induced Weight Loss on Energy Metabolism

The E-MECHANIC Ancillary Study will measure changes in 24-hour energy expenditure and spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study. We aim to determine if changes in energy metabolism might explain why people don't lose the expected amount of weight in an exercise program.

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Key information

Conditions

Metabolism Behavior Body Weight Body Weight Changes Motor Activity Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

About this study

This is an ancillary study to E-Mechanic, which is an National Institutes of Health study in 198 individuals with the objective to understand why certain people fail to lose weight in exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and energy expenditure are measured before and after 3 different exercise programs of 24 weeks in duration. The 3 exercise programs being compared are self-directed exercise, low dose exercise and high dose exercise. The goal of this ancillary study is to undertake comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese individuals enrolled in the main study. We will compare differences in the changes in 24h energy expenditure and spontaneous physical activity between the 3 exercise programs. We will also test if changes in energy metabolism might explain why people don't lose the expected amount of weight after 24 weeks of exercise.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals enrolled in the E-MECHANIC main study (NCT#01264406) with a body mass index (BMI) greater than or equal to 30 kg/m2.

Exclusion criteria

  • Not enrolled in the E-MECHANIC main study (NCT#01264406).
  • Have a body mass index (BMI) less than 30 kg/m2.

Treatment and study plan

Primary outcomes

  1. Change in 24h energy expenditure

    Time frame: 24 weeks

    24h energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program

Secondary outcomes

  1. Metabolic adaptation in 24h energy expenditure

    Time frame: 24 weeks

    The difference between the actual change in 24 energy expenditure and the energy expenditure estimated on the basis of body size will be compared between: 1) exercise groups and 2) between individuals who lost the expected amount of weight and individuals who did not lose the expected amount of weight during the exercise program

Other outcomes

  1. Sleeping energy expenditure

    Time frame: 24 weeks

    Sleeping energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program

  2. Spontaneous physical activity

    Time frame: 24 weeks

    Spontaneous physical activity will be measured in a room calorimeter before and after a 24 week exercise program

Sponsors and collaborators

Lead sponsor

Pennington Biomedical Research Center

Other

Registry information

Official study title

E-MECHANIC Ancillary Study: Effect of Exercise-Induced Weight Loss on Energy Metabolism

Important dates

Study start
2010
Primary completion
2015
Study completion
2015
First posted
Jan 24, 2013
Registry last updated
Aug 24, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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