Effect of ERAS and Upper Limb Exercise on LoS After Modified Radical Mastectomy

The goal of this clinical trial is to learn if Enhanced Recovery After Surgery (ERAS) protocol and upper limb exercise shorten the length of stay (LoS) in adults after modified radical mastectomy (MRM) surgery. The main questions it aims to answer are:

• Do ERAS protocol and upper limb exercise shorten the LoS after modified radical mastectomy (MRM)? Researchers will compare the ERAS protocol and upper limb exercise intervention to standard care to determine whether these interventions reduce LoS.

Four weeks before surgery, participants in intervention group will do:

* Aerobic exercise by walking for 30 minutes at moderate intensity (Borg scale 12-14) with frequency twice a week and by cycling for 30 minutes at moderate intensity (40-60% HRR / 64-76% HRmax/RPE 12-14) with frequency three times a week. * Strengthening exercise of lower limbs three times a week, intensity 60-80% 1RM, 3 set, 10 repetition, rest 60 seconds between sets by machine pulley. * Strengthening exercise of upper limbs at intensity 60-80% 1RM, frequency three times a week, 10 repetition, rest 60 seconds by bench press and cable front raise. * Stretching exercise of upper limbs and range of motion exercise frequency three times a week, hold 10 seconds, by static stretching.

After surgery, both groups will do:

• Mobilization, ambulation, and shoulder range of motion exercise in first 24 hours after surgery.

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Key information

Conditions

Modified Radical Mastectomy Behavior Motor Activity

Age range

30 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Prof. Dr. R. D. Kandou General Hospital

Manado, North Sulawesi, Indonesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women aged 30-65 years
Diagnosed with breast cancer by histopathological examination and will undergo the first MRM surgery
Planned to undergo neoadjuvant chemotherapy
Hemodynamically stable (assessed by vital signs)
Mini Mental State Examination (MMSE) score > 25
Comorbid diseases are controlled
Corrected nutritional status
No balance or coordination disorders
Normal or corrected vision function
Normal hearing function as tested by whisper test
Willing and agree to participate in the study until completion and sign informed consent

Exclusion criteria

Presence of distant metastasis
Presence of lymphedema
Limited joint range of motion
Other cardiovascular conditions that contraindicate physical exercise according to the American College of Sports Medicine (ACSM) guidelines

Treatment and study plan

Enhanced Recovery After Surgery

Behavioral

Four weeks before surgery, participants in intervention group will do:

Aerobic exercise by walking for 30 minutes at moderate intensity (Borg scale 12-14) with frequency twice a week and by cycling for 30 minutes at moderate intensity (40-60% HRR / 64-76% HRmax/RPE 12-14) with frequency three times a week.
Strengthening exercise of lower limbs three times a week, intensity 60-80% 1RM, 3 set, 10 repetition, rest 60 seconds between sets by machine pulley.

Upper Limb Exercise

Behavioral

Four weeks before surgery, participants in intervention group will do:

Strengthening exercise of upper limbs at intensity 60-80% 1RM, frequency three times a week, 10 repetition, rest 60 seconds by bench press and cable front raise.
Stretching exercise of upper limbs and range of motion exercise frequency three times a week, hold 10 seconds, by static stretching.

Primary outcomes

Length of Stay

Time frame: From the date of surgery until hospital discharge, assessed up to 10 days

Length of stay after Modified Radical Mastectomy

Sponsors and collaborators

Lead sponsor

Prof. R. D. Kandou General Hospital

Other

Registry information

Official study title

The Effect of Enhanced Recovery After Surgery and Upper Limb Exercise on Length of Stay After Modified Radical Mastectomy

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: May 7, 2026
Registry last updated: May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed