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OpenTrials
Completed

NCT Number: NCT00630123

Effect of Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation(TMS) on Brain Derived Neurotrophic Factor (BDNF) in Depressed Patients.

To investigate the change in brain derived neurotrophic factor (BDNF) between pre and post treatment for patients with depression with either ECT or TMS.

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Providence Care Mental Health Services

Kingston, Ontario, K7L4X3, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • MDD or bipolar disorder;
  • current depressive episode, ham-d17>17 and ymrs<8;
  • recommended to receive ECT or TMS as part of clinical care;
  • male/female;
  • age 18-65;
  • inpatient or outpatient;
  • comorbid dysthymic disorder, gad, or social anxiety will be included;
  • able to give written consent and agree.

Exclusion criteria

  • current manic, hypomanic, or mixed episode, ymrs>7;
  • current schizophrenia, anorexia, bulimia, substance dependence (current within past 6 months excluding caffeine and nicotine);
  • TMS or ECT in the last 3 months;
  • any other primary diagnosis;
  • uncontrolled medical illness;
  • epilepsy or severe personality disorder at the discretion of the investigators;
  • 3 weeks prior to first blood test, antidepressants, mood stabilizers, antipsychotics can not be added or increased;
  • pregnant women or women of childbearing potential not willing to use appropriate contraception, nursing women;
  • known intolerance or lack of response to treatment receiving as judged by the investigator;
  • medical conditions that would affect serum levels of BDNF;
  • involvement in planning and conduct of the study.

Treatment and study plan

Primary outcomes

  1. Serum levels of BDNF.

    Time frame: pre and post treatment

Secondary outcomes

  1. Correlation between the change in BDNF levels and illness severity after treatment.

    Time frame: pre and post treatment

Sponsors and collaborators

Lead sponsor

Queen's University

Other

Registry information

Official study title

Effect of Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation (TMS) on Serum Levels of Brain Derived Neurotrophic Factor in Depressed Patients.

Important dates

Study start
2006
Primary completion
2012
Study completion
2012
First posted
Mar 6, 2008
Registry last updated
Dec 16, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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