Effect of Different Dialysis Dosage on Prognosis in Maintenance Peritoneal Dialysis Patients

To investigate the effect, feasibility and safety of 6L of dialysate per day after initiation of peritoneal dialysis (PD), we perform a prospective, randomized, controlled, multi-center clinical study. The patients initiation of PD treatment within 6 months are randomized to be assigned to two groups: 6L of dialysate per day and 8L of dialysate per day, follow up will be regularly performed at baseline, 4 weeks, 8 weeks, 12 weeks, 24 weeks, 36 weeks, 48 weeks, 60 weeks, 72 weeks, 84 weeks and 96 weeks. Serum biochemical parameters, Kt/V, residual renal function (RRF), life quality and cardiovascular test will be regularly recorded. Clinical outcomes such as mortality, technique failure, complications and life quality between the two groups will be investigated.

Inclusion criteria

• Age from 18 to 80, male or female.
• End stage renal disease patients (eGFR < 15 ml/min/1.73 m2).
• Maintenance peritoneal dialysis within 6 months after initiation of PD.
• With informed consent.

Exclusion criteria

• Acute renal injury.
• Patients with an expected follow up less than 6 months sch as renal transplantation.
• Transferred from hemodialysis or renal transplantation.
• Residual renal function eGFR less than 1 ml/min.
• HIV positive.
• Cancer patients.
• Unstable organ disease such as active tuberculosis and severe hepatitis. Patients with an expected follow up less than 48 weeks, such as planned kidney transplant.
• Other conditions regarded as unsuitability by investigator, such as pregnancy, severe malnutrition and recent peritonitis.