Effect of Dietary Fat When Eaten With Fructose Versus Glucose

After 2 screening visits including an exercise test, DEXA and CT scan, qualifiers begin a 7 day diet with 20% fat, 65% carbohydrate (with 20% glucose) and 15 % protein. Participants consume 2 meals per day at PBRC with lunch and weekend meals packed to go. Following a test day, participants are randomized to one of 3 diet assignments and then test again:

1)20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein 2)40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein 3)40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein On Day 7 and again 14 days later participants have labs, an oral Glucose tolerance test, hepatic and intramuscular lipid measures by MRS, vital signs and waist measurement.

Inclusion criteria

• BMI between 25 and 35 kg/m2 inclusive
• At least one of the following:

• Impaired fasting glucose between 100-125 mg/dl inclusive
• HDL below 40 mg/dl for men or below 50 mg/dl for females
• Triglycerides between 150 mg/dl and 400 mg/dl inclusive
• Blood pressure above or equal to 135 / 85 mm Hg
• Waist circumference >94cm (37 inches) for men or >80cm for women
• Mainly Healthy

Exclusion criteria

• Unable or unlikely to eat study foods and only foods provided by PRBC
• Taking routine medications except birth control pills
• Smoke, Abuse drugs,or Alcohol
• Pregnant or breastfeeding, irregular menstrual cycles, Post-menopausal,or PCOS
• Diabetes, heart, lung, liver, blood, or Kidney disease