Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance

The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance exercise training study. The investigators aim to establish the potential mechanisms that might mediate performance changes at a cellular level.

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Key information

Conditions

Exercise-induced Inflammation

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Loughborough University

Leicester, LE11 3TU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Males
Healthy

Exclusion criteria

Resistance exercise training within the past 6 months
Vitamin or fish oil supplementation over the past 6 months
Habitual use of anti-inflammatory drugs
History of heart disease
History of coagulation/bleeding disorder
History of metabolic disease
Serious allergy
Known to have blood-borne virus
Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured)
Currently no symptoms of general illness

Treatment and study plan

Fish Oil

Dietary Supplement

Fish Oil Capsule

Other names: n-3 PUFA, Omega-3

Placebo

Dietary Supplement

Olive Oil capsule manufactured to mimic fish oil capsule

Other names: Olive Oil

Primary outcomes

Strength

Time frame: Change from baseline strength at 11 weeks

Quadriceps and Hamstring strength using an isokinetic dynamometer
Leg power

Time frame: Change from baseline strength at 11 weeks

Dynamic leg power assessed through jump height on force platform

Sponsors and collaborators

Lead sponsor

Loughborough University

Other

Registry information

Official study title

Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance, Inflammation, Gene Expression and Epigenetic Signatures

Acronym: FAT

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Aug 23, 2017
Registry last updated: Mar 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed