Skip to main content
OpenTrials
Completed

NCT Number: NCT01273831

Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

The purpose of this study is to determine which drug makes lower intraocular pressure

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Intraocular Pressure

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Al-zahra university hospital

Isfahan, Iran

About this study

Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion criteria

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Treatment and study plan

Atracurium

Drug

atracurium, Drop,0.5 mg/kg, one time, one day

Cisatracurium

Drug

cisatracurium, drop,0.15mg/kg,one time, one day

Primary outcomes

  1. intraocular pressure

    Time frame: at 2 minutes after intubation

    determining intraocular pressure in atracurium and cisatracurium groups

Secondary outcomes

  1. systolic blood pressure

    Time frame: at 2 minutes after intubation

    identification of systolic blood pressure in atracurium and cisatracurium groups

Sponsors and collaborators

Lead sponsor

Isfahan University of Medical Sciences

Other

Registry information

Official study title

Study of Effects of Cisatracurium and Atracurium on Intraocular Pressure

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Jan 11, 2011
Registry last updated
Jan 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.