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OpenTrials
Completed

NCT Number: NCT05401409

Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease

People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may contribute, in part, to high blood pressure in this condition. Nitrate is found in high concentrations naturally in beetroots, and increases NO. The aim of this study is to determine if beetroot juice reduces blood pressure in hypertensive people with ADPKD.

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Key information

Conditions

Autosomal Dominant Polycystic Kidney Abnormalities, Multiple Cardiovascular Diseases Ciliopathies Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endothelial Dysfunction Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genetic Diseases, Inborn Hypertension Kidney Diseases Kidney Diseases, Cystic Male Urogenital Diseases Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Westmead Hospital, Sydney, New South Wales, Australia

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of Autosomal Dominant Polycystic Kidney Disease
  • Age > 18 years old
  • Estimated Glomerular Filtration Rate (eGFR) > 30 mL/min/1.73m2
  • Treatment with at least one anti-hypertensive

Exclusion criteria

  • Inability to provide Informed Consent
  • Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit
  • Non-compliance with study procedures and/or daily BP measurements during the screening period
  • Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs; cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolemia; pregnancy or post-partum and lactating)
  • Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c > 10%)
  • Dislike of taste of beetroot juice
  • Allergy to beetroot
  • Enrolled in other clinical trials

Treatment and study plan

Beetroot juice

Dietary Supplement

70mls beetroot juice (400mg nitrate) given daily for 4 weeks

Other names: Beet It Sport Shot

Nitrate-depleted beetroot juice

Dietary Supplement

70mls beetroot juice (nitrate-depleted) given daily for 4 weeks

Primary outcomes

  1. Change in Clinic Systolic and Diastolic Blood Pressure From Baseline to 4 Weeks (End of Study)

    Time frame: 4 weeks

    Change in systolic and diastolic blood pressure over two time points - from readings taken at baseline (visit 1) compared with readings taken at 4 weeks (which was the end of the study; visit 3)

Secondary outcomes

  1. Average Change in Daily Home Systolic and Diastolic Blood Pressure Per Week, Over 4 Weeks

    Time frame: 4 weeks

    Reported change in blood pressure is average change per week, over 4 weeks

  2. Urinary Albumin to Creatinine Ratio at Baseline and at 4 Weeks (End of Study)

    Time frame: 4 weeks

  3. Change in Serum Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study)

    Time frame: 4 weeks

  4. Change in Salivary Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study)

    Time frame: 4 weeks

  5. Serum Asymmetric Dimethylarginine at Baseline and at 4 Weeks (End of the Study)

    Time frame: 4 weeks

    Asymmetric dimethylarginine (ADMA) which is a recognized marker of endothelial dysfunction and inhibitor of nitric oxide

Sponsors and collaborators

Lead sponsor

Western Sydney Local Health District

Other

Collaborators

  • Westmead Institute for Medical Research

Registry information

Official study title

Double-Blind, Randomised Placebo-Controlled Study to Determine the Effect of Beetroot Juice on Reducing Blood Pressure in Hypertensive Adults With Autosomal Dominant Polycystic Kidney Disease

Acronym: BEET-PKD

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 2, 2022
Registry last updated
Jun 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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