Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients

CI/SVI increase amplitude and maintenance time

Inclusion criteria

• Age ≥ 18 years old, gender unlimited
• Shock requires volume resuscitation:

Insufficient tissue perfusion: wet and cold skin, decreased urine volume (<0.5ml/kg/h), change of consciousness, blood lactate >2.0mmol/l or vasoactive drugs are required to maintain map>65mmhg

• Presence of volume reactivity: (under controlled ventilation) PPV ≥ 15% or passive leg raising test (+) or (under controlled ventilation) IVC variability ≥ 18% or the presence of volume reactivity as judged by clinicians
• The patient has no obvious restlessness, RASS ≤ 0
• The legal representative of the subject signs the informed consent form-

Exclusion criteria

• Pregnant and lactating women
• End stage patients
• BMI ≤ 15 or BMI ≥ 50
• Contraindication of indwelling central vein catheter and invasive arterial catheter
• Patients in ECMO and / or IABP therapy
• Hemorrhagic shock, blood products such as concentrated red blood cells, plasma and platelets will be infused within 1 hour
• Myocardial infarction, NYHA grade IV
• Patients with hyperkalemia, hypercalcemia, hypermagnesemia and hypothyroidism
• Allergic to compound sodium acetate ringer injection or albumin or with known side effects
• Other factors that may affect the monitoring and evaluation of relevant indicators