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NCT Number: NCT07670390

Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock

This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion. Eligible patients requiring fluid resuscitation will undergo a standardized fluid challenge test. Hemodynamic parameters, including cardiac output and TPP, will be recorded before and after fluid administration. Fluid responsiveness will be defined according to the change in cardiac output following fluid loading. The study will assess the correlation between changes in TPP and cardiac output and evaluate the diagnostic performance of TPP for predicting fluid responsiveness. The results may support the use of TPP as a practical and physiologically relevant parameter for individualized fluid management in patients with shock.

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Key information

Conditions

Shock Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Admitted to the Intensive Care Unit (ICU)
  • Diagnosed with shock and evidence of tissue hypoperfusion
  • Judged by the treating physician to require fluid resuscitation
  • Receiving invasive hemodynamic monitoring
  • Written informed consent obtained from the patient or legally authorized representative

Exclusion criteria

  • Pregnancy
  • Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices
  • Expected survival less than 72 hours
  • Absence of invasive arterial pressure monitoring or arterial waveform availability <25%
  • Any condition deemed unsuitable for study participation by the investigator.

Treatment and study plan

When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr

Behavioral

Primary outcomes

  1. Δ Cardiac output

    Time frame: Periprocedural

  2. Δ Tissue perfusion pressure

    Time frame: Periprocedural

Study contacts

Contact information is provided by the study sponsor or research team.

Jingyuan Xu

CONTACT

[email protected]

8602583262550

Sponsors and collaborators

Lead sponsor

Jingyuan,Xu

Other

Registry information

Official study title

Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock: A Prospective Observational Study

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jun 26, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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