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OpenTrials
Completed

NCT Number: NCT04795102

Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants

Immediate implant placement into fresh extraction sockets is gaining popularity because of fewer clinical procedures and maintenance of bone architecture compared to conventional methods, thus reducing the treatment time and increasing patient satisfaction. In addition, the survival rate of the immediate implantation is comparable to that of the healed implantation sites. Recently, ATBG made from compromised teeth was applied in bone defects and resulted in a good clinical efficacy. Moreover, it is more accepted by patients to use extracted teeth as a bone graft material, especially in the case of immediate implant placement. In 2020, Kizildağ and coworkers studied the outcome of PRF as an adjunct with ATBG on bone healing in rabbit peri-implant osseous defects. They reported that combination of ATBG with PRF contributed to significantly higher new bone formation and better bone/implant contact in rabbits with peri-implant bone defects. The main hypothesis behind this study is that using L-PRF with ATBG following immediate implant placement could promote stabilization of graft particles and enhance new bone formation with a shorter time. Therefore, the purpose of this study was to compare the clinical and radiographic outcomes of ATBG on bone formation with or without L-PRF around immediately placed dental implants in periodontally compromised teeth.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Kafrelsheikh University

Kafr ash Shaykh, 33511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Teeth need to be extracted for periodontal reasons with a defect of labial bone (horizontal or vertical bone defect).
  • the teeth without acute inflammation.
  • no uncontrolled systemic disease which is not suitable for implantation.
  • Good systemic and oral health.

Exclusion criteria

  • patients with systemic diseases or medications known to alter healing processes
  • Psychiatric disorders.
  • Root canal treated teeth.
  • patients undergoing or who had undergone radiation therapy and chemotherapy to the head and neck region during 12 months.
  • patients with para-functional habits.
  • alcoholics.
  • drug abusers.
  • heavy smokers

Treatment and study plan

immediate implant placement with ATBG and L-PRF

Combination Product

immediate implant placement using ATBG as a graft material, with L-PRF

immediate implant placement with ATBG

Combination Product

immediate implant placement using ATBG as a graft material without L-PRF

Primary outcomes

  1. clinical evaluation of bone formation around immediately placed dental implants

    Time frame: 9 months

    Changes on bone formation using ATBG with or without L-PRF around immediately placed dental implants in periodontally compromised teeth

  2. radiographic outcome around immediately placed dental implants

    Time frame: 9 months

    the radiographic outcome of ATBG on bone formation with or without L-PRF around immediately placed dental implants in periodontally compromised teeth

Sponsors and collaborators

Lead sponsor

Dalia Rasheed Issa

Other

Registry information

Official study title

Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants in Periodontally Compromized Sites: A Randomized Clinical Trial

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Mar 12, 2021
Registry last updated
Sep 2, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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