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Completed

NCT Number: NCT00731926

Effect of Antioxidant on Endurance Performance in Healthy Men

oligomerized litchi fruit extract may enhance the submaximal endurance exercise performance

Completed

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Key information

Conditions

Exercise Tolerance

Age range

20 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2 / Phase 3

About this study

Regular physical exercise has many beneficial effects, but it has been reported that strenuous exercise could elevate the production of free radical and other reactive oxygen species (ROS) which eventually injure the tissues and decrease the muscle function.So many kinds of antioxidant supplementations have been tried to decrease the muscle fatigue and enhance the exercise performance. polyphenolic flavonoids abundant in fruits and leafy vegetables have strong antioxidant effect. oligomerized litchi fruit extract has strong antioxidant capacity and higher bioavailability compared to that of grape seed polyphenol. The aim of this study was to determine whether oligomerized litchi fruit extract could induce endurance exercise performance more than Vit C + Vit E mixture or placebo could do. Therefore, we designed double blind randomized controlled trial, setting the change of running time to exhaustion under submaximal treadmill test as the primary endpoint.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy men over 20 years old non-smoker

Exclusion criteria

  • BMI>25 or body fat>25% he who intakes the antioxidant supplement in recent 2 weeks

Treatment and study plan

Oligomerized litchi fruit extract

Dietary Supplement

100mg at once twice a day for 1 month

Other names: oligonol; brand name of oligomerized litchi fruit extract

VItamin C + Vitamin E mixture

Dietary Supplement

Vitamin C 400mg + Vitamin E 160IU at once twice a day for 1 month

Placebo

Other

twice a day for 1 month

Primary outcomes

  1. change of running time to exhaustion under 80% of maximal heart rate

    Time frame: 1 month

Secondary outcomes

  1. VO2max, anaerobic threshold

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • University of California, Davis

Registry information

Official study title

Effect of Antioxidant on Endurance Performance in Healthy Men -Double Blind Randomized Placebo and Active Controlled Trial-

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Aug 11, 2008
Registry last updated
Aug 12, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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