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Completed

NCT Number: NCT05628935

Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

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Key information

Conditions

Inflammation Anesthesia Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zonguldak Bülent Ecevit University Medicine Faculty

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Underwent forearm surgery
  • Between aged 18-70
  • Under general anesthesia or peripheral nerve block

Exclusion criteria

  • acute infection
  • morbid obesity
  • chronic treatment with steroids or immunosuppressants
  • recently received chemotherapy
  • hepatic and renal dysfunction;
  • chronic alcohol abusers
  • Multiple trauma
  • Patients with missing data in their files

Treatment and study plan

Peripheral nerve block

Procedure

local anesthetic application to the brachial plexus

Primary outcomes

  1. Neutrophil/lymphocyte ratio

    Time frame: up to 24 hours after surgery

    Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

Secondary outcomes

  1. Platelet/lymphocyte ratio

    Time frame: up to 24 hours after surgery

    Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

  2. Mean Platelet Volume

    Time frame: up to 24 hours after surgery

    Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block

Sponsors and collaborators

Lead sponsor

Zonguldak Bulent Ecevit University

Other

Registry information

Official study title

The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery

Important dates

Study start
2018
Primary completion
2020
Study completion
2021
First posted
Nov 29, 2022
Registry last updated
Nov 29, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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