Effect of an Low Carbon High Fat Diet on Pain- and Quality of Life in Patients With Lipedema

Lipedema is a chronic disease with unproportional, symmetrical fat accumulation in the lower extremities. Patients experience pain in affected areas, and reduced quality of life. Today's treatment is physiotherapy and surgery (liposuction). Recent research shows that ketogenic-diet with low carbohydrate, high fat (LCHF) conant can lead to reduced pain, increased quality of life and change in body composition. Goals: Investigate the effect of LCHF diet on pain, quality of life and body composition.

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Key information

Conditions

Lipedema Body Weight Connective Tissue Diseases Neurologic Manifestations Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Morbid Overnutrition Overweight Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin and Connective Tissue Diseases

Age range

18 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Obesity Clinic, St Olavs Hospital

Trondheim, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

weight stable over the last three months (+ 2-3 kg)
not currently dieting to loose weight.
willing to meet for weekly follow-ups during the intervention and the reintroduction of a regular diet.
sign an informed consent before entering the study.

Exclusion criteria

pregnant or breast feeding
history of infectious diseases
medication known to affect obesity
enrolment in any other obesity treatment
have had a bariatric surgery
history of psychological disorders
mentally disabled
not mastering a Scandinavian language
having a malign disease or any disease that leads to dietary advice that is not consistent with intervention advices in the study

Treatment and study plan

Low carbohydrate high fat diet

Dietary Supplement

Energy balanced low carbohydrate high fat diet during 6 weeks. Then 6-week reintroduction of a healthy normal diet

Other names: ketogenic diet

Primary outcomes

Lymphedema Quality of Life questionnaire

Time frame: 6 weeks
Pain indicated on a visual analog scale

Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Helse Nord-Trøndelag HF

Other

Collaborators

St. Olavs Hospital
University of Oslo

Registry information

Acronym: LIPODIET

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Oct 18, 2018
Registry last updated: Feb 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed