Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema

Study design RCT comparing a low-energy ketogenic diet to a non-ketogenic low-energy diet (non-keto) in females with lipedema. This study was approved by the Reginal Ethical Committee (REK 93888) All participants have to provided written informed consent in line with the Helsinki Declaration, before entering the study. Participants will be randomized by block randomization with stratification by BMI categories.

Study population Females diagnosed with lipedema, aged 18-75 years old, and a BMI between 30-45 kg/m2, will be invited to participate in this study. Participants had to be diagnosed with lipedema by physiotherapists before inclusion. Inclusion criteria includs weight stability for the last three months (±3 kg).

Dietary interventions Diets were matched for energy (1200 kcal/day) and protein, but differed in carbohydrate (CHO) and fat content.

The dietary plans are adjusted with respect to food preferences, intolerances, and allergies. The participants will be asked not to change their physical activity levels throughout the study period.

Compliance Participants will have weekly follow-ups. Participants will be asked to fill out daily food records throughout the intervention period.

Ketostix will be used in the weekly follow-ups to measure urinary acetoacetate (AcAc). If the participants in the keto group were outside of ketosis, or participants in the non-keto group in ketosis, >2 times throughout the study period, they were excluded from the per-protocol (PP) analysis.

Outcome variables

The following variables were assessed at baseline and at the end of the intervention:

Anthropometrics and body composition Height and weight will be measured at baseline. Body composition will be assessed in fasting state with Bioelectrical Impedance Analysis before and after the intervention..

Pain Pain will be assessed with the brief Pain Inventory. The participants rated their pain in a numerical rating scale (NRS), where 0 = no pain and 10 = Worst imaginable pain. The BPI assesses pain intensity: strongest pain, weakest pain, average pain, pain now, pain severity score using an average of pain intensity domains, and pain inference from daily activities, mood, walking, regular work, relationships, sleep and life joy. A pain inference score is also computed as the average of all pain inference domains.

Three different questionnaires are used to assess Quality of life. RAND-36. The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) q and the Lymphoedema Quality of Life (LYMQOL).

Inclusion criteria

• Diagnosed with lipedema by skilled physical therapists
• Body mass index > 30kg/m2 and < 45kg/m2
• Stable weight over the last three months (+2-3kg)
• Not currently dieting to lose weight
• Willing to meet for follow-ups every second week during the intervention
• Willing to sign an informed consent before entering the study

Exclusion criteria

• Pregnant or breast feeding
• History of infectious diseases
• Medication known to affect obesity
• Enrolled in any other obesity treatment
• Having had bariatric surgery.
• Kidney disease is excluded
• History of psychological disorders
• Not mastering a Scandinavian language
• Being mentally disabled
• Malign disease
• Diabetes
• Any disease that leads to dietary advice that is not consistent with intervention advice