Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP

Platelet-rich fibrin (PRF) is commonly used to enhance gum tissue healing and reducing pain after tooth extraction and before placing a dental implant. 44 patients requiring a tooth extraction will be recruited and randomized to receive a collagen plug with or without platelet-rich fibrin.

Inclusion criteria

• Age range: 20 to 80 years.
• Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
• Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)
• Patients interested in implant placement following tooth extraction.

Exclusion criteria

• Allergies or hypersensitivities to study related medications.
• Hematologic disorders/blood dyscrasias.
• Active infectious diseases of any kind.
• Liver or kidney dysfunction/failure.
• Uncontrolled diabetes (HbA1c > 8).
• Active cancer treatment - such as active chemotherapy or radiation therapy.
• Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).
• Metabolic bone diseases that affect bone healing such as osteoporosis.
• Pregnant or lactating women (self-reported).
• Smoke 10 or more cigarettes per day (self-reported).
• Poor oral hygiene.
• Systemic diseases that compromise the immune system
• Anti-coagulant therapy