Effect of Aerobic Interval Training on Cardiovascular Function in Aging

Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.

Inclusion criteria

for older adults:

• Healthy men and women 55 to 79 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.

Inclusion criteria

for young adults:

• Healthy men and women 18 to 35 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.

Exclusion criteria

• history of diabetes
• history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
• hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
• history of renal impairment
• history of gout or hyperuricemia
• history of hepatic disease or infection with hepatitis B, C
• history of seizures, or other relevant on-going or recurrent illness
• recent (within 3 months) or recurrent hospitalizations
• use of tobacco products
• >5 % weight change in the prior 6 months.
• current intake of medications that may affect study results
• participation in regular aerobic exercise training (>30 minutes,

• 3 times/wk in the past year).
• premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
• pregnancy (positive urine pregnancy test) or lactation