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Completed

NCT Number: NCT07002970

Effect of Aerobic Exercise and Mediterranean Diet on Obese Patients

All study group patients performed aerobic exercise on a treadmill. approved by the American College of Sports Medicine.

Both groups received a Mediterranean diet for 12 weeks tailored according to patients' caloric needs

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Key information

Age range

35 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Physical Therapy

Cairo, Egypt

About this study

All study group patients performed aerobic exercise on a treadmill approved by the American College of Sports Medicine. The program started with a warming-up phase through walking on a treadmill for 3-5 minutes at a slow speed. Then, 10-30 minutes of aerobic exercise training with moderate intensity (60-70% of maximum heart rate) and 10 minutes of cooling down with low speed and without inclination. Participants had 3 sessions/week for 3 months with close supervision of a physical therapist.

Both groups received a Mediterranean diet for 12 weeks tailored to patients' caloric needs. They received instructions about the consumption of olive oil as added lipid, the consumption of nuts and olives as snacks, daily high consumption of vegetables, fruits, and whole grains, dairy products, bi-weekly consumption of legumes, bi-weekly consumption of fish, and monthly consumption of meat. The main beneficial components of the Mediterranean diet are monounsaturated fats such as oleic acid in olive oil, polyunsaturated fats such as omega-3, high amounts of flavonoids and antioxidants found in fruits and vegetables, and high amounts of fiber found mainly in foods with a low glycemic index

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obese patients with BMI ranged from 30-39.9 kg/m 2.
  • Their age was from 35 to 45 years old.
  • Both genders.
  • Stable vital signs (blood pressure, respiratory rate and temperature)
  • Abdominal obesity measurements according to American heart association)
  • Obese patients have one or more abnormal value of lipids profile.
  • All patients with sedentary life style.
  • All patients had insulin resistance

Exclusion criteria

  • Rheumatic, neurologic, cardiovascular, respiratory, renal, lung problems, malignant tumors, and undiagnosed fever, which would prevent them from participating in aerobic exercises.
  • Knee injury or knee surgery during the past six month or having a history of joint replacement or fracture or hereditary or acquired musculoskeletal disorders in lower limb.
  • Major vision disorders.
  • Drugs that would affect metabolism or balance.
  • Assistive devices for walking.
  • Pregnancy or breast feeding, and post-partum 12 months.
  • Abdominal or rectal anus surgery.

Treatment and study plan

aerobic exercise program

Other

All study group patients performed aerobic exercise on a treadmill. approved by the American College of Sports Medicine.

Mediterranean Diet

Other

received a Mediterranean diet for 12 weeks tailored according to patients caloric needs

Primary outcomes

  1. Short Form Quality of Life Questionnaire (SF-36)

    Time frame: 12 weeks

    To measure the health related quality of life (HRQOL)in obese patient. SF-36 (version 2.0) is a 36-item measure of generic HRQOL in which 35 questions are transformed into eight dimensions; physical functioning, role limitation to physical problems, bodily pain, general health, vitality, social functioning, role limitations to emotional problems, and mental health Scores on all eight dimensions range from zero to 100, where higher scores represent better HRQOL

Secondary outcomes

  1. Laboratory Measurements

    Time frame: 12 weeks

    After a 12-hour overnight fast, venous blood samples were collected from each participant in all participants before and after 12 weeks of treatment to measure, LDL, HDL, total cholesterol, TG levels milligrams per deciliter (mg/dL) and fasting blood glucose (FBG) measured in mg/dL (milligrams per deciliter) ,C-reactive protein (CRP) measured in milligrams per liter (mg/L), and (ESR) was measured in millimeters per hour (mm/hr) and fasting serum insulin measured and reported in micro International Units per milliliter (uIU/mL) by commercially available kits. All samples were drawn between 8 and 10 a.m. for later analysis.

  2. Blood Pressure Measures

    Time frame: 12 weeks

    Systolic and diastolic blood pressures were measured for each participant before and after 12 weeks of treatment

  3. body weight

    Time frame: 12 weeks

    Body weight was measured for each participant in kilograms

  4. height

    Time frame: 12 weeks

    body height was measured for each participant in meters

  5. waist and hip circumferences

    Time frame: 12 weeks

    waist and hip circumferences were measured for each participant in centimeter

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Combined Effect of Aerobic Exercise and Mediterranean Diet on Inflammatory Markers and Quality of Life in Obese Patients

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jun 4, 2025
Registry last updated
Jun 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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