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NCT Number: NCT06784271

Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes

The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidad de la Laguna

Santa Cruz de Tenerife, Spain

About this study

Capsaicin appears to enhance athletic performance by reducing perceived effort, increasing mechanical performance (e.g., total volume load), and decreasing muscle damage. Given the close relationship between the metabolic and physiological responses of cross-training and supplementation with Phenylcapsaicin (PC), it could be expected that consuming capsaicin during cross-training would have a favorable impact on perceived effort, recovery, and performance.

25 women and 24 men trained in CrossFit consumed either Phenylcapsaicin (PC) or a placebo during a CrossFit class, which consisted of a 16-minute weightlifting segment and a 15-minute WOD. Both the Rating of Perceived Exertion (RPE) and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-35 years.
  • Body mass index: 18.5-30 kg/m2.
  • Ability to understand the instructions, objectives, and study protocol.
  • Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
  • Resident on the island of Tenerife.

Exclusion criteria

  • History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
  • Any chronic pathology in which the intake of nutritional supplements, especially pungent components, is not recommended.
  • Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
  • Use of medications that may affect the study results.
  • Unstable body weight for 3 months prior to the start of the study (> 4 kg loss or gain in weight).
  • Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse.
  • On a special diet or prescribed for other reasons (e.g., celiac disease).

Treatment and study plan

Phenylcapsaicin

Dietary Supplement

2.5mg of Phenylcapsaicin

Placebo

Dietary Supplement

Placebo

Primary outcomes

  1. Performance

    Time frame: 60min

    Performance measured through the countermovement jump

  2. Performance

    Time frame: 60min

    Deep squat test at 70% of repetition maximum

Secondary outcomes

  1. Heart rate

    Time frame: 60min

    Heart rate will be measured with the Polar H10 heart rate monitor

  2. Subjective fatigue throughe the RPE scale

    Time frame: 60min

    Rate of perceived exertion scale

  3. Recovery

    Time frame: 60min

    Perceived Recovery Status Scale (RPS)

  4. Delayed-onset muscle soreness (DOMS)

    Time frame: 60min

    Delayed-onset muscle soreness (DOMS) scale (0-10 arbitrary units)

  5. Capillar lactate levels

    Time frame: 60min

    Capillar lactate levels

  6. Performance: Weight used in the crosstraining session

    Time frame: 60min

    Weight used in the crosstraining session

  7. Performance: Time performed in the crosstraining session

    Time frame: 60min

    Time performed in the crosstraining session

Sponsors and collaborators

Lead sponsor

Universidad de Granada

Other

Collaborators

  • Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.

Registry information

Official study title

Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes: a Randomized, Placebo-Controlled Crossover Study

Acronym: CROSSCAPS

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 20, 2025
Registry last updated
Jan 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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