Effect of Acupuncture on the Success Rate in Patients With Recurrent Implantation Failure

Inclusion criteria

• Meets the criteria for RIF diagnosis (≥ 2 instances of unsuccessful transfer of high-quality embryos).
• Age: 20 to 40 years old.
• Planning for a cycle involving the transfer of frozen-thawed embryos (FET).
• Possession of a transplantable D3 frozen embryo (≥6 cells) or a frozen blastocyst (≥3BC).
• Estradiol-progesterone replacement therapy: endometrial thickness ≥ 7 mm within the period of endometrial transformation.

Exclusion criteria

• Individuals planning to undergo preimplantation genetic diagnosis (PGD).
• Recipients of egg donations.
• Chromosomal abnormalities in either spouse or one partner (excluding chromosomal polymorphisms).
• Patients with known embryo-related factors leading to implantation failure.
• Abnormalities of the uterus that may affect implantation (including uterine malformations, uterine tuberculosis, submucosal myomas, severe uterine adhesions, severe uterine endometriosis, myomas with a diameter of ≥4 cm, and so on).
• Recurrent spontaneous abortions (loss of a fetus before 28 weeks of gestation occurring twice or more).
• Individuals with other endocrine disorders, such as thyroid disorders, hyperprolactinemia, insulin resistance, diabetes, and adrenal disorders, whose hormone levels have not been well-controlled over the past 3 months.
• Individuals with untreated hydrosalpinx;
• Individuals with a Body Mass Index (BMI) below 18 and above 25 kg/m2.
• Men with severe abnormalities in semen quality. Individuals with a history of needle phobia.