Effect of 8-Week Dietary DHA Supplementation on Cerebral Blood Flow and Metabolic Function

Inclusion criteria

• Male subjects between the ages of 8 - 10 years.
• Not breast-fed during infancy
• Right hand dominant
• Attending school at appropriate grade level
• Normal body-mass index (BMI)
• Ability and willingness to provide assent and informed, written consent from at least one biological parent.
• Present with biological parent
• No current general medical or psychiatric illness.
• Medication free.
• Normal intelligence as assessed by the Kaufman Brief Intelligence Test.
• Willingness to maintain current dietary habits.

Exclusion criteria

• Inability or unwillingness to provide consent.
• Antecedent or concurrent serious medical illness.
• A lifetime history of any significant axis I psychiatric disorder ( i.e. bipolar disorder, schizophrenia)
• Patients who have received any psychoactive medications, current and lifetime.
• Clinically unstable medical disease, including cardiovascular, hepatic insufficiency, severe renal impairment, gastrointestinal, pulmonary, metabolic, endocrine, obesity or other systemic disease.
• History of seizures, excluding febrile seizures in childhood.
• Patients requiring treatment with any drug which might obscure the action of study the study treatment.
• Less than normal intelligence.
• Pacemaker
• Cerebral aneurysm clip
• Cochlear implant
• Metal fragments lodged within the eye
• Claustrophobia
• Necessity of sedation (no sedation will be given).
• History of loss of consciousness > 10 minutes in duration
• Adopted