Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma

At present, the common used contrast agent in ERCP is composed of ionic and non-ionic type, and the latter's advantages lie in its slighter toxic-and-side effect and favorable security. When heated to 37℃, the 20 ℃ contrast agents would be diluted to 50% consistency, then a shorter time period of its intravascular and other intracavitary stay would add to less cell damage. And the applications of heated non-ionic contrast agents could be found in computed tomography angiography(CTA), hysterosalpingography (HSG) and cystourethrography, and consequently the patients with the intervention of heated non-ionic contrast agents felt more comfortable and fewer adverse reactions could be observed. Nevertheless, heated contrast agent was rarely reported to act in ERCP. It's theoretically possible that its heat-reduced lower mucosity could help the contrast agent itself to drainage, so that the incidence of cholangeitis could be under control.

Inclusion criteria

• Type Ⅰ、Ⅱ、Ⅲ、Ⅳ of Hilar Cholangiocarcinoma;
• Age: 18~90 years old;
• Underwent diagnostic and therapeutic ERCP;

Exclusion criteria

• Coagulation dysfunction(INR>1.3) or/and low peripheral blood platelet count （PLT <50x10^9/L）;
• Preoperative acute cholangitis;
• Preoperative acute pancreatitis;
• Preoperative hemobilia or hemorrhage of digestive tract;
• Preoperative liver failure;
• Combined with Mirizzi syndrome and intrahepatic bile duct stones;
• Preoperative malignant tumor of biliary system such as carcinoma of head of pancreas, gallbladder carcinoma;
• Biliary-duodenal fistula confirmed during ERCP;
• A history of reconstructive surgery for upper digestive tract except Billroth Ⅰand a history of cholangioenterostomy including cholangio-jejunostomy and side to side anastomosis of the bile duct and duodenum;
• Previous ERCP;
• Pregnant women