ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis

This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under 18 years old with an underlying oncologic diagnosis and/or hematopoietic stem cell transplant on Extracorporeal membrane oxygenation (ECMO). In a small multicenter cohort, the comparative analysis evaluated survival outcomes in this population with respiratory failure in the presence and absence of ECMO. Children's Mercy Kansas City served as the ECMO cohort; Cincinnati Children's Hospital Medical Center served as the matched non-ECMO cohort.

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Key information

Conditions

ECMO Outcomes Hematologic Diseases Hematologic Neoplasms Hematopoetic Stem Cell Transplant Hemic and Lymphatic Diseases Malignancies, Hematologic Neoplasms Neoplasms by Site Respiration Disorders Respiratory Failure (Pediatric Patients) Respiratory Insufficiency Respiratory Tract Diseases Solid Tumor Malignancies

Age range

4 week–17 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Less than 18 years old
Admitted to the PICU for respiratory failure (2015-2023)
Underlying oncologic diagnosis and/or hematopoietic stem cell transplant
Mechanical ventilation

Treatment and study plan

Extracorporeal membrane oxygenation (ECMO)

Other

ECMO utilization in patient with malignancy and/or history of hematopoietic stem cell transplant.

Primary outcomes

Comparison of survival rates in pediatric patients with an underlying malignancy and/ or hematopoietic stem cell transplant in the presence and absence of ECMO support

Time frame: Admission until hospital discharge, average of 46 days

Sponsors and collaborators

Lead sponsor

Children's Mercy Hospital Kansas City

Other

Collaborators

Children's Hospital Medical Center, Cincinnati

Registry information

Important dates

Study start: 2015
Primary completion: 2024
Study completion: 2025
First posted: Jul 20, 2026
Registry last updated: Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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