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OpenTrials
Completed

NCT Number: NCT03823885

ECigs, Inflammation and Oxidative Stress

Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.

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Key information

Conditions

E-cigarettes, Oxidative Stress, Inflammation Behavior Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Smoking Vaping

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UCLA

Los Angeles, California, 90095, United States

About this study

Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy

Exclusion criteria

  • Cardiac disease Respiratory disease Diabetes

Treatment and study plan

E-Cigarette

Other

use e-cig for 30 minutes

Other names: e-cig

empty (-cigarette sham control)

Other

use empty e-cig (sham control)

Other names: empty e-cig

Primary outcomes

  1. Cellular Reactive Oxygen Species, units = % fluorescence

    Time frame: within 4 hours of E-cig use

    cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells

Secondary outcomes

  1. CD 14+ Monocyte, units = % of total cells

    Time frame: within 4 hours of e-cig use

    CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Collaborators

  • Tobacco Related Disease Research Program

Registry information

Official study title

E-Cigarettes and Monocytes

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Jan 31, 2019
Registry last updated
Oct 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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