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OpenTrials
Completed

NCT Number: NCT01821742

Echocardiography in Kids Intensive Care Decision Support

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU.

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Key information

Conditions

Fluid Responsiveness Cardiac Output Pathologic Processes Pathological Conditions, Signs and Symptoms Shock

Age range

Up to 16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Imperial College Healthcare NHS Trust

London, W2 1NY, United Kingdom

About this study

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU. These parameters will be measured pre and post fluid bolus in children prescribed fluid bolus therapy for clinical indications on the PICU. Children will be classified as responders (>10% increase in cardiac output) and non responders (<10% increase). Appropriate statistical tests will be performed to determine the most useful predictor of an increase in cardiac output following a fluid bolus.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any ventilated child requiring fluid bolus therapy on the PICU for clinical indications

Exclusion criteria

  • Arrythmia
  • Intracardiac shunt

Treatment and study plan

Ultrasound cardiac output measurement

Other

Primary outcomes

  1. Fluid responsiveness

    Time frame: Immediate

    10% increase in cardiac output following fluid bolus

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Registry information

Official study title

Echocardiography in Kids Intensive Care Decision Support - is Focused Echocardiography Superior to Pressure Derived Measurements at Predicting Fluid Responsiveness in Critically Ill Children?

Acronym: ECHOKIDS

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Apr 1, 2013
Registry last updated
Jul 8, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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