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OpenTrials
Completed

NCT Number: NCT03932617

Correlation Between Changes in End-Tidal Carbon Dioxide and Stroke Volume Variation Detected by Electrical Cardiometry as A Predictor of Fluid Volume Responsiveness in Hemodynamically Unstable Patients in the Intensive Care

This study will be conducted to assess the role of end-tidal carbon dioxide (PETCO2) monitoring to predict the fluid volume responsiveness in correlation with stroke volume variation detected by electrical cardiometry in patients with hemodynamic instability.

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Key information

Conditions

End Tidal Carbon Dioxide Cardiometry Fluid Responsiveness Pathologic Processes Pathological Conditions, Signs and Symptoms Shock

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Tanta University Hospitals

Tanta, ElGharbiaa, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who will be 18 years or older.
  • Patients on mechanical ventilation in the intensive care.
  • Patients developing hypotension (MABP) <65 mmHg.

Exclusion criteria

  • Patients with organ/s failure at presentation.
  • Patients with deep venous thrombosis.
  • Patients with limb and pelvic fractures.
  • Pregnant patients

Treatment and study plan

end tidal carbon dioxide by capnography

Device

Moreover, since PETCO2 is mainly determined by tissue CO2 production (VCO2), alveolar ventilation and CO, when stable metabolic conditions are assumed and minute ventilation is kept constant, acute changes in PETCO2 have been shown to correlate strongly with changes in CO.

Thus, PETCO2 has been suggested as a simple economic and noninvasive alternative for continuous assessment of CO in different shock states.

Primary outcomes

  1. Assessment of sensitivity and specificity of end tidal carbon dioxide monitoring in predicting fluid responsiveness in correlation with stoke volume variation detected by cardiometry

    Time frame: 24 hour

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
May 1, 2019
Registry last updated
Feb 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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