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Completed

NCT Number: NCT02973724

EC95 of Remifentanil for Preventing Cough

The investigator designed this study to investigate remifentanil effect-site concentration in 95% of patients (EC95) for preventing cough after laryngomicrosurgery from propofol anesthesia.

Completed

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Key information

Conditions

Drug Usage

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ajou University Hospital

Suwon, Gyeonggi-do, 443-721, South Korea

About this study

At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). Extubation was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II patients undergoing general anesthesia for laryngomicrosurgery

Exclusion criteria

  • Anticipated difficult airway
  • COPD, Asthma
  • Recent URI (< 2 weeks)
  • Severe cardiac, hepatic renal disease

Treatment and study plan

Remifentanil

Drug

The concentration of remifentanil was determined by biased-coin up and down design, starting from 1.0 ng/ml (0.4 ng/ml as a step size)

Other names: Ultiva

propofol anesthesia

Drug

Anesthesia was induced with propofol target-controlled infusion at an effect-site concentration of 5.0 μg/ml.

Other names: Fresofol

Primary outcomes

  1. Number of cough

    Time frame: from end of surgery to 5 min after tracheal extubation

    Number of cough or a strong and sudden contraction of the abdomen during periextubation periods

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Official study title

Predicted EC95 of Effect-site Concentration of Remifentanil for Preventing Cough After Laryngomicrosurgery From Propofol Anesthesia

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Nov 25, 2016
Registry last updated
Jun 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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