EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.

The exhibition is evaluated by population pharmacokinetic modeling.

Completed

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Key information

Conditions

Infection Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Rennes

Rennes, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age over 18 years
Hospitalisation in intensive care
Treatment with ECMO or without ECMO
Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours
With an arterial catheter
Patient Information or their next of kin according to the patients status.

Exclusion criteria

Pregnancy
Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty

Treatment and study plan

blood sample

Other

Primary outcomes

Measure exposure to piperacillin

Time frame: Day 1

evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Acronym: EC-MOTION

Important dates

Study start: 2016
Primary completion: 2019
Study completion: 2019
First posted: Sep 28, 2016
Registry last updated: Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed