Eating Disorders in Patients With Phenylketonuria

The prevalence of eating disorders and BMI are significantly higher in PKU patients than in the general population. The protein-restricted diet associated with high carbohydrate intake and the severity of the genetic defect and disease can lead to weight gain in these patients; However, the link between restrictive diets, EDs, and obesity has not been demonstrated in patients with PKU. These issues remain poorly explored, meaning that patients may not be detected and treated.

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Key information

Conditions

Phenylketonuria Amino Acid Metabolism, Inborn Errors Brain Diseases Brain Diseases, Metabolic Brain Diseases, Metabolic, Inborn Central Nervous System Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Metabolic Diseases Metabolism, Inborn Errors Nervous System Diseases Nutritional and Metabolic Diseases Phenylketonurias

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Nancy

Nancy, 54000, France

Location status: Recruiting

Location contact

Eva Feigerlova, MD, PhD, MMEd

CONTACT

00330383154796

Feigerlova

CONTACT

[email protected]

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects followed for PKU at Nancy University Hospital
Subjects willing to participate

Exclusion criteria

Subjects not villing to participate

Treatment and study plan

Primary outcomes

Phenotypes related to TCA in the PCU cohort of the Reference Center for Hereditary Metabolic Diseases

Time frame: from january 2026 to january 2028

Study contacts

Contact information is provided by the study sponsor or research team.

Eva Feigerlova, MD PhD MMEd

CONTACT

[email protected]

+330383154796

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: TCA-PKU

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: Jul 13, 2026
Registry last updated: Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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